Abstract
The amplification refractory mutation system (ARMS) is a simple and rapid method of detecting point mutations, restriction fragment length polymorphisms, and small deletions or insertions of a DNA sequence. The method was first described by Newton et al. (1) for the analysis of single nucleotide differences in DNA from patients with α − 1 antitrypsin deficiency and has since been applied for the carrier detection and prenatal diagnosis of many other genetics disorders including cystic fibrosis (2), β thalassaemia (3), and sickle cell disease (4).
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References
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© 2000 Humana Press Inc., Totowa, NJ
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Old, J.M. (2000). The Amplification Refractory Mutation System. In: Rapley, R. (eds) The Nucleic Acid Protocols Handbook. Springer Protocols Handbooks. Humana Press, Totowa, NJ. https://doi.org/10.1385/1-59259-038-1:723
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DOI: https://doi.org/10.1385/1-59259-038-1:723
Publisher Name: Humana Press, Totowa, NJ
Print ISBN: 978-0-89603-459-4
Online ISBN: 978-1-59259-038-4
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