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Serum and tissue levels of six trace elements and copper/zinc ratio in patients with cervical cancer and uterine myoma

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Abstract

The aim of this study is to investigate the relationship between trace elements and the incidence of cervical cancer. Tissue and serum levels of six elements (Cu, Zn, Fe, Mn, Ca, and Se) and the Cu/Zn ratio in 40 cases of patients with cervical cancer, 30 cases of uterine myoma, and 50 healthy subjects were measured by atomic absorption spectrophotometry; the selenium content was determined by atomic fluorescence spectrometry. The results showed that the tissue contents of Zn, Se, and Ca were significantly lower and the Cu and Fe concentrations and Cu/Zn ratio were significantly higher in cervical cancer tissue than that for paired nonlesion tissue (p<0.02 and p<0.001, respectively). The serum levels of Zn, Se, Ca, and Fe were lower and Cu and Mn levels and Cu/Zn ratio were higher in patients with cervical cancer than in healthy subjects (p<0.01 and p<0.001, respectively) and in the uterine myoma group compared with healthy subjects (p< 0.05–0.001). There are no significant differences in the contents of six elements and the Cu/Zn ratio between uterine myoma tissue and paired nonlesion tissue. The results showed also that the Fe level and Cu/Zn ratio were significantly higher and the Zn and Se levels were significantly lower in cervical cancer tissue than in uterine myoma tissue (p<0.01 and p<0.001, respectively). The serum Cu level and Cu/Zn ratio were significantly higher in the cervical cancer group than the uterine myoma group (p<0.01). Data were also analyzed using multivarate logistic regression. After adjustment for age, occupation, life habit, and other covariates for the development of cervical cancer, the odds ratios were 22.64 (95% confidence interval [CI]: 5.64–90.88, p=0.001) for Cu, 0.11 (95% CI: 0.034–0.373; p=0.005) for Zn, and 0.60 (95% CI: 0.36–0.99, p=0.01) for Se. Thus, the serum and tissue levels of Cu increase and the deficiency of Zn and Se may be risk factors for the development of cervical cancer.

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References

  1. W. G. Li, Q. S. Huang, S. Y. Yu, et al., Six-year prospective observation on ingesting selenium-salt to prevent primary liver cancer, Chin. J. Cancer 12, 108–110 (1993).

    Google Scholar 

  2. Y. J. Zhang, J. X. Jing, C. Z. Han, et al., Impairment of antioxidant system in human esophageal cancer, Chin. J. Exp. Surg. 19, 182–183 (2002).

    Google Scholar 

  3. N. Manuel, G. Ander, R. Gilles, et al., Urinary selenium excretion in patients with cervical uterine cancer, Biol. Trace Element Res. 79, 97–105 (2001).

    Article  Google Scholar 

  4. J. V. Selby and G. D. Friedman, Epidemiologic evidence of an association between body iron store and risk of cancer, Int. J. Cancer 44, 677–682 (1988).

    Article  Google Scholar 

  5. L. A. Van Asperen, E.J.M. Feskens, C. H. Bowles, et al., Body iron stores and mortality due to cancer and ischemic heart disease: a 17-year follow-up study of elderly men and women, Int. J. Epidemiol. 24, 665–670 (1995).

    Article  PubMed  Google Scholar 

  6. J. I. Wurzermann, A. Silver, D. M. Schreinemachers, et al., Iron intake and risk of colorectal cancer, Cancer Epidemiol. Biomarkers Prev. 15, 503–507 (1996).

    Google Scholar 

  7. X. W. Zhao, C. Z. Han, et al., Relationship of serum trace elements to lung cancer and clinical application, Chin. J. Epidemiol. 19, 286–290 (1998).

    CAS  Google Scholar 

  8. H. Y. Wu, L. Y. Yu, L. G. Xu, et al., Clinical study on serum copper, zinc levels and copper/zinc ratio in malignant lymphoma, Chin. J. Oncol. 10, 335–337 (1988).

    Google Scholar 

  9. M. David, N. Ondrer, S. Vaclan, et al., Serum levels of selenium, manganese, copper and iron in colorectal cancer patients, Biol. Trace Element Res. 79, 107–114 (2001).

    Article  Google Scholar 

  10. C. Z. Han, J. X. Jing, et al., Relationship between trace elements in hair and esophageal cancer, Acta Nutr. Sin. 17, 431–433 (1995).

    Google Scholar 

  11. C. Z. Han, X. B. Liang, W. Su, et al., Study on the association and significance between trace elements and rectal cancer, Chin J. Epidemiol. 20, 166–169 (1999).

    CAS  Google Scholar 

  12. M. L. Slattery, A. W. Sovenson, and M. H. Ford, Dietary calcium intake as a mitigating factor in colon cancer, Am. J. Epidemiol. 128, 504–513 (1988).

    PubMed  CAS  Google Scholar 

  13. G. Yang, Y. T. Gao, B. T. Ji, et al., A case-control study on colorectal cancer and dietary fiber and calcium of various sources, Chin. J. Met. Prev. 28, 195–198 (1994).

    CAS  Google Scholar 

  14. L. Wang, S. L. Qu, et al., Effect of added dietary calcium on human esophageal cancer, Chin. J. Tumor 12, 332–335 (1994).

    CAS  Google Scholar 

  15. A. Chan, F. Wong, and M. Arumanayagam, Serum ultrafiltrable copper, total copper and ceruloplasmin concentrations in gynecological carcinomas, Ann. Clin. Biochem. 30, 545–549 (1993).

    PubMed  Google Scholar 

  16. M. Zowczak, M. Iskra, L. Torimski, et al., Analysis of serum copper and zinc concentrations in cancer patients, Biol. Trace. Element Res. 82, 1–8 (2001).

    Article  CAS  Google Scholar 

  17. Y. Y. Cheng, C. Z. Han, J. X. Jing, et al., The correlation of trace elements with ovarian cancer and clinical application value, J. Shanxi Med. 26, 493–495 (1997).

    CAS  Google Scholar 

  18. C. Z. Han, J. X. Jing, et al., Classification and prognostic value of serum copper/zinc ratio in hodgkin’s disease, Biol. Trace Element Res. 83, 133–138 (2001).

    Article  CAS  Google Scholar 

  19. J. Machacek, P. Mensik, and V. Bicik, Serum levels of copper and zinc in breast cancer and its possible using in clinical practice, New Clin. Oncol. 6, 112–116 (1984).

    Google Scholar 

  20. A. S. Prasad, Zinc in human health: an update, Trace Elements Exp. Med. 11, 63–87 (1998).

    Article  CAS  Google Scholar 

  21. P. M. Newberne, T. F. Schrager, and S. Broitman, Esophageal carcinogenesis in the rat: zinc deficiency and alcohol effects on tumor inductions, Pathobiology 65, 39–45 (1997).

    Article  PubMed  CAS  Google Scholar 

  22. M. Sciezska, A. Danch, M. Machalski, et al., Plasma selenium concentration in patients with stomach and colon cancer in the upper Silesia, Neoplasma 44, 395–397 (1997).

    Google Scholar 

  23. D. Psathakis, N. Wedemyer, E. Oevermann, et al., Blood selenium and gluthathione peroxidase status in patients with colorectal cancer, Dis. Colon Rectum 41, 328–335 (1998).

    Article  PubMed  CAS  Google Scholar 

  24. V. Singh and A. N. Garg, Trace element correlations in the blood of Indian women with breast cancer, Biol. Trace Element Res. 64, 237–245 (1998).

    CAS  Google Scholar 

  25. I. Kato, A. M. Dnistrian, M. Schwartz, et al., Iron intake, body iron stores and colorectal cancer risk in women: a nested case-control study, Int. J. Cancer. 80, 693–698 (1999).

    Article  PubMed  CAS  Google Scholar 

  26. A. C. Chua and E. H. Morgan, Effects of iron deficiency and iron overload on manganese uptake and deposition in the brain and other organs of the rat. Biol. Trace Element Res. 55, 39–54 (1996).

    Article  Google Scholar 

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Authors and Affiliations

  1. Department of Etiology, Shanxi Cancer Institute, 030013, Taiyuan, People’s Republic of China

    Han Cunzhi, Jing Jiexian, Zhao Xianwen, Guo Jingang & Du Lili

  2. Department of Gynecology, Shanxi Tumor Hospital, 030013, Taiyuan, People’s Republic of China

    Zheng Shumin

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  1. Han Cunzhi
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  2. Jing Jiexian
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  3. Zhao Xianwen
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  4. Guo Jingang
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  5. Zheng Shumin
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  6. Du Lili
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Cunzhi, H., Jiexian, J., Xianwen, Z. et al. Serum and tissue levels of six trace elements and copper/zinc ratio in patients with cervical cancer and uterine myoma. Biol Trace Elem Res 94, 113–122 (2003). https://doi.org/10.1385/BTER:94:2:113

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  • DOI: https://doi.org/10.1385/BTER:94:2:113

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