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Natural patterns of neural activity

How physiological mechanisms are orchestrated to cope with real life

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Abstract

Physiological mechanisms of neuronal information processing have been shaped during evolution by a continual interplay between organisms and their sensory surroundings. Thus, when asking for the functional significance of such mechanisms, the natural conditions under which they operate must be considered. This has been done successfully in several studies that employ sensory stimulation under in vivo conditions. These studies address the question of how physiological mechanisms within neurons are properly adjusted to the characteristics of natural stimuli and to the demands imposed on the system being studied. Results from diverse animal models show how neurons exploit natural stimulus statistics efficiently by utilizing specific filtering capacities. Mechanisms that allow neurons to adapt to the currently relevant range from an often immense stimulus spectrum are outlined, and examples are provided that suggest that information transfer between neurons is shaped by the system-specific computational tasks in the behavioral context.

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  1. Lehrstuhl für Neurobiologie, Fakultät für Biologie, Universität Bielefeld, Postfach 10 01 31, D-33501, Bielefeld, Germany

    Rafael Kurtz & Martin Egelhaaf

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Kurtz, R., Egelhaaf, M. Natural patterns of neural activity. Mol Neurobiol 27, 13–31 (2003). https://doi.org/10.1385/MN:27:1:13

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