Skip to main content
Log in

Antibodies for neoplastic disease

Solid tumors

  • Review
  • Published:
Molecular Biotechnology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Liu, S. Y. and Press, O. W. (1997) The potential for immunoconjugates in lymphoma therapy. Haematol. Oncol. Clin. North Am. 11, 987–1006.

    Article  CAS  Google Scholar 

  2. Frankel, A. E., Laver, J. H., Willingham, M. C., Burns, L. J., Kersey, J. H., and Vallera, D. A. (1997) Therapy of patients with T-cell lymphomas and leukemias using an anti-CD7 monoclonal antibody-ricin A chain immunotoxin. Leuk. Lymphoma 26, 287–298.

    PubMed  CAS  Google Scholar 

  3. LoRusso, P. M., Lomen, P. L., Redman, B. G., Poplin, E., Bander, J. J., and Valdivieso, M. (1995) Phase I study of monoclonal antibody-ricin A chain immunoconjugate Xomazyme-791 in patients with metastatic colon cancer. Am. J. Clin. Oncol. 18, 307–312.

    Article  PubMed  CAS  Google Scholar 

  4. Laske, D. W., Muraszko, K. M., Oldfield, E. H. et al. (1997) Intraventricular immun-otoxin therapy for leptomeningeal neoplasia. Neurosurgery 41, 1039–1049.

    Article  PubMed  CAS  Google Scholar 

  5. Chen, S. Y., Yang, A. G., Chen, J. D. et al. (1997) Potent antitumour activity of a new class of tumour-specific killer cells. Nature 385, 78–80.

    Article  PubMed  CAS  Google Scholar 

  6. Yarranton, G. (1998) Antibody-calicheamicin conjugates for the treatment of cancer. Antibody Engineering. New Technology, Application and Commercialisation. IBC event code IB 146. March 2–3, The Royal Society, London, UK.

    Google Scholar 

  7. Liu, C., Tadayoni, B. M., Bourret, L. A. et al. (1996) Eradication of large colon tumor xenografts by targeted delivery of maytansinoids. Proc. Natl. Acad. Sci. USA 93(16), 8618–8623.

    Article  PubMed  CAS  Google Scholar 

  8. Press, O. W., Eary, J. F., Appelbaum, F. R. et al. (1993) Radiolabelled-antibody therapy of B-cell lymphoma with autologous bone marrow support. N. Engl. J. Med. 329, 1219–1224.

    Article  PubMed  CAS  Google Scholar 

  9. Goldenberg, D. M., ed. (1995) Cancer Therapy with Radiolabelled Antibodies. CRC, Boca Raton, FL.

    Google Scholar 

  10. Blumenthal, R. D., Sharkey, R. M., Natale, A. M., Kashi, R., Wong, G., and Goldenberg, D. M. (1994) Comparison of equitoxic radioimmunotherapy and chemotherapy in the treatment of human colonic cancer xenografts. Cancer Res. 54, 142–151.

    PubMed  CAS  Google Scholar 

  11. Hird, V., Maraveyas, A., Snook, D. et al. (1993) Adjuvant therapy of ovarian cancer with radioactive monoclonal antibody. Br. J. Cancer 68(2), 403–406.

    PubMed  CAS  Google Scholar 

  12. Canevari, S., Miotti, S., Bottere, F., Valota, O., and Colnaghi, M. I. (1993) Ovarian carcinoma therapy with monoclonal antibodies. Hybridoma 12, 501–507.

    PubMed  CAS  Google Scholar 

  13. Riva, P., Tison, V., Arista, A., et al. (1993) Radioimmunotherapy of gastrointestinal cancer and glioblastomas. Int. J. Biol. Markers 8, 192–197.

    PubMed  CAS  Google Scholar 

  14. Welt, S., Divgi, C.R., Kemeny, N., et al. (1994) Phase I/II study of iodine 131-labelled monoclonal antibody A33 in patients with advanced colon cancer. J. Clin. Oncol. 12, 1561–1571.

    PubMed  CAS  Google Scholar 

  15. Riva, P., Arista, A., Tison, V., et al. (1994) Intralesional radioimmunotherapy of malignant glioma. An effective treatment in recurrent tumours. Cancer 73, 1076–1082.

    Article  PubMed  CAS  Google Scholar 

  16. Kalofonos, H. P., Pawlikowska, T. R., Hemingway, A., et al. (1989) Antibody guided diagnosis and therapy of brain gliomas using radiolabelled monoclonal antibodies against epidermal growth factor receptor and placental alkaline phosphatase. J. Nucl. Med. 30, 1636–1645.

    PubMed  CAS  Google Scholar 

  17. Grana, C., Chinol, M., Magnani, P., et al. (1996) In vivo tumour targeting based on the avidin-biotin system. Tumour Targeting 2, 230–239.

    Google Scholar 

  18. Stillwagon, G. B., Order, S. E., Klein, J. L., et al. (1987) Multi-modality treatment of primary nonresectable intrahepatic cholangiocarcinoma with I-131 anti-CEA: a Radiation Therapy Oncology Group Study. Int. J. Radiat. Oncol. Biol. Phys. 13, 687–695.

    PubMed  CAS  Google Scholar 

  19. Order, S. E., Stillwagon, G. B., Klein, J. L., et al. (1985) Iodine-131-antiferritin, a new treatment modality in hepatoma: a Radiation Therapy Oncology Group Study. J. Clin. Oncol. 3, 1573–1582.

    PubMed  CAS  Google Scholar 

  20. Order, S. E., Vriesendorp, H. M., Klein, J. L., and Leichner, P. K. (1988) A phase I study of 90yttrium antiferritin: dose escalation and tumour dose. Antibody Immunoconj. Radiopharm. 1, 163–168.

    Google Scholar 

  21. Zeng, Z. C., Tang, Z. Y., Xie, H., et al. (1993) Radioimmunotherapy for unresectable hepatocellular carcinoma using 131-Hepama-1 mAb: preliminary results. J. Cancer Res. Clin. Oncol. 119, 257–259.

    Article  PubMed  CAS  Google Scholar 

  22. Siegel, J. A., Pawlyk, D. A., Lee, R. E., et al. (1990) Tumor, red marrow and organ dosimetry for 131I-labelled anti-carcinoembryonic antigen monoclonal antibody. Cancer Res. 50, 1039s-1042s.

    PubMed  CAS  Google Scholar 

  23. Thirion, S., Motmans, K., Heyligen, H., Janssens, J., Raus, J., and Vandevyver, C. (1997) Mono- and bispecific single-chain antibody fragments for cancer therapy. Euro. J. Can. Prev. 5, 507–511.

    Google Scholar 

  24. Canevari, S., Stoter, G., Arienti, F. et al. (1995) Regression of advanced ovarian carcinoma by intraperitoneal treatment with autologous T lymphocytes retargeted by a bispecific antibody. J. Natl. Cancer Inst. 87, 1463–1469.

    Article  PubMed  CAS  Google Scholar 

  25. Valone, F. H., Kaufman, P. A., Guyre, P. M. et al. (1995) Phase Ia/Ib trial of bispecific antibody MDX-210 in patients with advanced breast or ovarian cancer that over-expresses the proto-oncogene HER-2/neu. J. Clin. Oncol. 13, 2281–2292.

    PubMed  CAS  Google Scholar 

  26. Riethmuller, G., Schneider-Gadicke, E., Schlimok, G. et al. (1994) Randomised trial of monoclonal antibody for adjuvant therapy of resected Dukes’ C colorectal carcinoma. German Cancer Aid 17-1A Study Group. Lancet 343, 1177–1183.

    Article  PubMed  CAS  Google Scholar 

  27. Jerne, N. K. (1974) Towards a network theory of the immune system. Ann. Immunol. C 25, 373–389.

    Google Scholar 

  28. Mittleman, A., Chen, Z. J., Kageshita, T. et al. (1990) Active specific immunotherapy in patients with melanoma. A clinical trial with mouse antiidiotypic monoclonal antibodies elicited with syngeneic antihigh-molecular-weight-melanoma-associated antigen monoclonal antibodies. J. Clin. Invest. 86, 2136–2144.

    Article  Google Scholar 

  29. Mittelman, A., Wang, X., Matsumoto, K., and Ferrone, S. (1995) Antiidiotypic response and clinical course of the disease in patients with malignant melanoma immunized with mouse antiidiotypic monoclonal antibody MK2-23. Hybridoma 14, 175–181.

    PubMed  CAS  Google Scholar 

  30. Frodin, J. E., Faxas, M. E., Hagstrom, B., et al. (1991) Induction of anti-idiotypic (ab2) and anti-anti-idiotypic (ab3) antibodies in patients treated with the mouse monoclonal antibody 17-1A (ab1). Relation to the clinical outcome-an important antitumoral effector function? Hybridoma 4, 421–431.

    Article  Google Scholar 

  31. Madiyalakan, R., Sykes, T. R., Dharampaul, S. et al. (1995) Antiidiotypic induction therapy: evidence for the induction of immune response through the idiotype network in patients with ovarian cancer after administration of anti-CA125 murine monoclonal antibody B43.13. Hybridoma 14, 199–203.

    PubMed  CAS  Google Scholar 

  32. Durrant, L. G., Buckley, T. J., Denton, G. W., Hardcastle, J. D., Sewell, H. F., and Robins, R. A. (1994) Enhanced cell-mediated tumor killing in patients immunized with human monoclonal antiidiotypic antibody 105AD7. Cancer Res. 54, 4837–4840.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Matthews, I.T.W. Antibodies for neoplastic disease. Mol Biotechnol 21, 91–97 (2002). https://doi.org/10.1385/MB:21:1:091

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1385/MB:21:1:091

Keywords

Navigation