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Detection of an mRNA polymorphism by differential display

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Abstract

Differential Display (DD) technology was utilized to compare programs of gene expression in primary cultures of human skin fibroblasts from normal volunteers and patients diagnosed with melancholic depression. Polymorphic transcripts of a single gene differing by one tandem repeat sequence of four nucleotides (TGAT) in the 3′ noncoding region were detected.

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References

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Authors and Affiliations

  1. Department of Cell Biology, Vanderbilt University Medical Center, 649 MRB II, 37232-6838, Nashville, TN

    Peng Liang

  2. Department of Psychiatry, Vanderbilt University Medical Center, Nashville, TN

    Shan Liang, S. Paul Rossby, Richard C. Shelton, D. Hal Manier, Amitabha Chakrabarti & Fridolin Sulser

  3. Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN

    Richard C. Shelton & Fridolin Sulser

  4. Department of Cell Biology, Vanderbilt University Medical Center, Nashville, TN

    Peng Liang

Authors
  1. Shan Liang
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  2. S. Paul Rossby
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  3. Peng Liang
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  4. Richard C. Shelton
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  5. D. Hal Manier
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  6. Amitabha Chakrabarti
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  7. Fridolin Sulser
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Liang, S., Rossby, S.P., Liang, P. et al. Detection of an mRNA polymorphism by differential display. Mol Biotechnol 19, 121–124 (2001). https://doi.org/10.1385/MB:19:2:121

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  • DOI: https://doi.org/10.1385/MB:19:2:121

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