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Identification and characterization of CD8+ suppressor T cells

  • Immunology at Emory University
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Abstract

It has long been appreciated that certain subsets of T cells are capable of suppressing immune reactions. Initially, such T cells were described as CD8+ suppressor T cells (Ts) and there is a vast body of research spanning 30 years that describes the immunobiology of CD8+ Ts. However, studies on CD8+ Ts have suffered from the inability to distinguish CD8+ Ts from CD8+ T cells of other phenotypes. Here we present a brief history of CD8+ Ts, a review of recent progress distinguishing CD8+ Ts as a unique subset of CD8+ T cells, and an overview of the evolving immunological context in which CD8+ Ts function.

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Author notes

  1. James C. Zimring MD, PhD

    Present address: Department of Pathology, Emory University School of Medicine, Woodruff Memorial Research Building, 101 Woodruff Circle, Room 7301, 30322, Atlanta, GA

Authors and Affiliations

  1. Department of Pathology, Emory University School of Medicine, Woodruff Memorial Research Building, 101 Woodruff Circle, Room 7301, 30322, Atlanta, GA

    Judith A. Kapp

  2. Department of Ophthalmology, Emory University School of Medicine, Atlanta, GA

    Judith A. Kapp

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  1. James C. Zimring MD, PhD
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  2. Judith A. Kapp
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Zimring, J.C., Kapp, J.A. Identification and characterization of CD8+ suppressor T cells. Immunol Res 29, 303–311 (2004). https://doi.org/10.1385/IR:29:1-3:303

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