Abstract
Behavioral pharmacology is the detection, description, and explanation of drug effects on behavior. It can be divided into four subsections:
-
1.
The neurochemical or physiological basis of behavior is investigated by using drugs with a known mechanism of action;
-
2.
Behavior is used to measure the potency, spectrum of action, and structure-activity relationships of drugs;
-
3.
Drugs can be used to produce models of pathological conditions; and
-
4.
The mechanism of action of drugs can be investigated, such as their electrophysiological or neurochemical basis.
These four areas clearly require different methods, and aggressive behavior can be used in all of them.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Similar content being viewed by others
References
Adams D. (1979) Brain mechanisms for offense, defense and submission. Behav. Brain Sci. 2, 201–241.
Albert D. J. and Walsh M. L. (1982) The inhibitory modulation of agonistic behavior in the rat brain: A review. Neurosa. Biobehav. Rev. 6, 125–143.
Altmann J. (1974) Observational study of behavior: Sampling methods. Behav. 49, 227–267.
Arnone M. and Dantzer R. (1980a) Does frustration induce aggression in pigs? Appl. Anim. Ethol. 6, 351–362.
Arnone M. and Dantzer R. (1980b) Effects of diazepam on extinction induced aggression in pigs. Pharmacol. Biochem. Behav. 13, 27–30.
Azrin N. H., Hutchinson R. R., and Hake D. (1963) Pain-induced fighting in the squirrel monkey. J. Exp. Anal. Behav. 6, 620–628.
Blanchard R. J. and Blanchard D. C. (1977) Aggressive behavior in the rat. Behav. Biol. 21, 197–224.
Blanchard D. and Blanchard R. J. (1984) Affect and aggression: An animal model applied to human behavior, in Advances in the Study of Aggression, vol. 1 (Blanchard R. J. and Blanchard D. C, eds.), Academic, New York, pp. 1–62.
Byrd L. D. (1973) Effects of D-amphetamine on schedule-controlled key pressing and drinking in the chimpanzee. J. Pharm. Exp. Ther. 185, 633–641.
Byrd L. D. (1977) Introduction: chimpanzees as biochemical models, in Progress in Ape Research (Bourne G. H., ed.), Academic, New York, pp. 161–165.
DaVanzo J. P., Daugherty M., Ruckart R., and Kang L. (1966) Pharmacological and biochemical studies in isolation-induced fighting mice. Psychopharmacologia 9, 210–215.
Dixon A. K. (1978a) Changes in the social behavior of mice after antidepressants and neuroleptics. Experientia 34, 923–926.
Dixon A. K. (1978b) Rodent social behavior in relation to biomedical research, in Dos Tier im Experiment (Weine W. H., ed.), Huber Verlac, Bern, pp. 128–146.
Flynn J. P., Vanegas H., Foote W., and Edwards S. (1970) Neural mechanisms involved in a cat’s attack on a rat, in The Neural Control of Behavior (Whalen R. E., ed.), Academic, New York, pp. 135–173.
Ginsberg B.E. and Allee W. C. (1942) Some effects of conditioning on social dominance and subordination in inbred strains of mice. Physiol. Zool. 15, 485–506.
Grant E. (1963) An analysis of the social behavior of the male laboratory rat. Behaviors. 21, 260–281.
Grant E. C. and Mackintosh J. H. (1963) A comparison of the social postures of some common laboratory rodents. Behaviors 21, 246–259.
Haccou P. (1986) Analysis of behavior by means of continuous time Markov chain models and their generalizations, in Quantitative Models in Ethology (Colgan P. W. and Zayan R., eds.), Privat. I. E. C., Toulouse, pp. 81–96.
Hess W. R. (1928) Stammganglien-reizversuche. Berichte der gesamten. Physiologie 47, 554.
Hess W. R. and Brugger M. (1943) Das subkortikale zentrum der affectiven abwehrreactionem. Helv. Physiol. Acta 1, 33–52.
Hunsperger R. W. and Bucher V. M. (1967) Affective behavior produced by electrical stimulation in the forebrain and brainstem of the cat, in Progr. Brain. Res. 27 (Adey W.R. and Tokizane T., eds.), Elsevier, Amsterdam, pp. 445–463.
Krsiak M. (1975) Timid singly-housed mice: Their value in prediction of psychotropic activity of drugs. Br. J. Pharmcol. 55, 141–150.
Lehman M. N. and Adams D. B. (1977) A statistical and motivational analysis of the social behaviors of the male laboratory rat. Behaviors LXI, 3-4, 238–275.
McGuire M. T. and Raleigh M. J. (1987) Serotonin, social behavior and aggression in vervet monkeys, in Ethophartnacology of Agonistic Behavior in Animals and Humans (Olivier B., Mos, J., and Brain P. F., eds.), Martinus Nijhoff, Boston, pp. 207–222.
Miczek K. A. (1987) The psychopharmacology of aggression, in Handbook of Psychopharmacology, Vol. 19 (Iversen L. L., Iverson S. D., and Snyder S. H., eds.), Plenum, New York, pp. 183–328.
Miczek K. A. and Barry H. (1974) ʔ-9-Tetrahydrocannabinal and aggressive behavior in rats. Behav. Biol. ii, 261–267.
Miczek K. A. and Barry H. (1976) Pharmacology of sex and aggression, in Behavioral Pharmacology (Glick S. D. and Goldfarb J., eds.), Mosby, St. Louis, pp. 176–257.
Miczek K. A. and Krsiak M. (1979) Drug effects on agonistic behavior, in Adv. Behav. Pharmacol. (Thompson T. and Dews P. eds.), Academic, New York, pp. 87–162.
Miczek K. A. and O’Donnell J. (1978) Intruder-evoked aggression in isolated and non isolated mice: Effects of psychomotor stimulants and L-Dopa. Psychopharmacology 57, 47–55.
Moyer K.E. (1968) Kinds of aggression and their physiological basis. Commun. Behav. Biol. 2, 65–87.
O’Kelly L. I. and Steckle L. C. (1939) A note on long enduring emotional responses in the rat. Arch. Int. Pharmacodyn. Ther. 2, 9, 125–131.
Olivier B., Van Aken H., Jaarsma I., Van Oorschot R., Zethof T., and Bradford L. D. (1984) Behavioral effects of psychoactive drugs on agonistic behavior of male territorial rats (resident-intruder model), in Ethopharmacological Aggression Research (Miczek K. R., Kruk M. R., and Olivier B., eds.), Alan R. Liss, New York, pp. 137–156.
Pellegrino L. and Cushman A. (1967) A Stereotaxic Atlas af the Rat Brain. Appleton-Century-Crofts, New York.
Poshivalov V. P. (1981) Pharmaco-ethological analysis of social behavior of isolated mice. Pharmacol Biochem. Behav. 14, 53–59.
Poshivalov V. P. and Khodko S. T. (1984) Mathematical description and experimental pharmaco-ethological analysis of animal intraspecific agonistic behavior, in Ethopharmacological Aggression Research (Miczek, K. A., Kruk, M. R., and Olivier B., eds.), Alan R. Liss, New York, pp. 59–80.
Scott J. P. (1966) Agonistic behavior of mice and rats: A review. Am. Zool. 6, 683–701.
Silverman A. P. (1966a) The social behavior of laboratory rats and the action of chlorpromazine and other drugs. Behaviors 27, 1–38.
Silverman A. P. (1966b) Barbiturates, lysergic acid diethylamine, and the social behavior of laboratory rats. Psychopharmacologia 10, 155–171.
Smith E. O. (1981) Device for capture and restraint of non human primates. Lab. Animal Sci. 31, 305–306.
Smith E. O. and Begeman M. L. (1980) Bores: Behavioral observation recording, and editing system. Behav. Res. Meth. Instrumentation 12, 1–7.
Tedeschi D. H., Fowler P. J., Miler R. and Macko E. (1969) Pharmacological analysis of foot shock-induced fighting, in Biology of Aggressive Behavior (Garattini S. and Sigg, H. eds.), Excerpta Medica Foundation, Amsterdam, pp. 245–252.
Tedeschi R. E., Tedeschi D. H., Mucha A., Cook L., Mattis P. A., and Fellows E. J. (1954) Effects of various centrally acting drugs on fighting behavior of mice. J. Pharmacol. Exp. Ther. 129, 28–34.
Ulrich R. R. and Azrin N. H. (1962) Reflexive fighting in response to aversive stimulation. J. Exp. Anal. Behav. 5, 511–520.
Ulrich R. R., Wolff P. C, and Azrin N. H. (1964) Shock as an elicitor of intra and inter species fighting behavior. Animal Behav. 12, 14,15.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1991 The Humana Press Inc.
About this protocol
Cite this protocol
H. Sheard, M. (1991). Methods for Drug Studies in Aggressive Behavior. In: Boulton, A.A., Baker, G.B., Martin-Iverson, M.T. (eds) Animal Models in Psychiatry, II. Neuromethods, vol 19. Humana Press, Totowa, NJ. https://doi.org/10.1385/0-89603-177-2:233
Download citation
DOI: https://doi.org/10.1385/0-89603-177-2:233
Publisher Name: Humana Press, Totowa, NJ
Print ISBN: 978-0-89603-177-7
Online ISBN: 978-1-59259-624-9
eBook Packages: Springer Protocols