Chest
Clinical InvestigationsEffects of Inhaled Anticholinergic Drug on Dyspnea and Gas Exchange During Exercise in Patients With Chronic Obstructive Pulmonary Disease
Section snippets
METHODS
We studied 19 male patients with stable COPD. The diagnosis was determined by patient history, the usual radiologic and pulmonary criteria, and persistent exertional dyspnea with signs of overdistended lung volume. The clinical and physiologic data are presented in Table 1. The mean age was 72.0 ± 1.9 years (range, 55 to 85 years). No patient had a forced expiratory volume in 1 s (FEV1) to more than 60 percent predicted, and no patient had more than 15 percent reversibility on β-adrenergic
RESULTS
Lung function measurements before study are summarized in Table 1. Mean pretreatment FEV1 was 1.28 ± 0.07 L, which was 40.5 ± 2.5 percent predicted. The mean changes in spirometric indices after each administration of agents are shown in Table 2. The FVC and FEV1 after OTB administration were significantly greater than those before administration, but not after placebo. After 15 min, the mean increase in FEV1 after OTB was 16.8 ± 0.9 percent of baseline value, and after placebo it was 0.3 ± 0.6
DISCUSSION
The usefulness of various inhaled bronchodilators, including anticholinergic agents, in COPD has been well established recently.1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 The bronchodilating effect of anticholinergic drugs seems to be superior to that of adrenergic agents in COPD and anticholinergic drugs seem not to induce tachyphylaxis.2, 6, 7, 8 Although the effects of anticholinergic drugs on spirometric indices and gas exchange in resting ventilation have been widely examined in COPD,1, 2, 3, 4, 5,
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Cited by (0)
This study was supported by Nippon Boerhinger-Ingelheim Co Ltd.
Manuscript received May 27; revision accepted October 12