On the Probability of Dizygotic Twins Being Concordant for Two Alleles at Multiple Polymorphic Loci

Dale R. Nyholt

doi:10.1375/twin.9.2.194

Abstract

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Accurate determination of same-sex twin zygosity is important for medical, scientific and personal reasons. Determination may be based upon questionnaire data, blood group, enzyme isoforms and fetal membrane examination, but assignment of zygosity must ultimately be confirmed by genotypic data. Here methods are reviewed for calculating average probabilities of correctly concluding a twin pair is monozygotic, given they share the same genotypes across all loci for commonly utilized multiplex short tandem repeat (STR) kits. Numerous tools enabling convenient and accurate zygosity probability calculation may be accessed via the ZygProb homepage at http://genepi.qimr.edu.au/general/daleN/ZygProb/

Crossref Citations

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Cornes, Belinda K. Zhu, Gu and Martin, Nicholas G. 2007. Sex Differences in Genetic Variation in Weight: a Longitudinal Study of Body Mass Index in Adolescent Twins. Behavior Genetics, Vol. 37, Issue. 5, p. 648.

Hansell, N. K. James, M. R. Duffy, D. L. Birley, A. J. Luciano, M. Geffen, G. M. Wright, M. J. Montgomery, G. W. and Martin, N. G. 2007. Effect of the BDNF V166M polymorphism on working memory in healthy adolescents. Genes, Brain and Behavior, Vol. 6, Issue. 3, p. 260.

Wise, P. M. Hansen, J. L. Reed, D. R. and Breslin, P. A. S. 2007. Twin Study of the Heritability of Recognition Thresholds for Sour and Salty Taste. Chemical Senses, Vol. 32, Issue. 8, p. 749.

Middelberg, Rita P. S. Martin, Nicholas G. and Whitfield, John B. 2007. A Longitudinal Genetic Study of Plasma Lipids in Adolescent Twins. Twin Research and Human Genetics, Vol. 10, Issue. 1, p. 127.

Pincombe, Jennifer L. Luciano, Michelle Martin, Nicholas G. and Wright, Margaret J. 2007. Heritability of NEO PI-R Extraversion Facets and Their Relationship With IQ. Twin Research and Human Genetics, Vol. 10, Issue. 3, p. 462.

Wright, Margaret J. Luciano, Michelle Hansell, Narelle K. Montgomery, Grant W. Geffen, Gina M. and Martin, Nicholas G. 2008. QTLs Identified for P3 Amplitude in a Non-Clinical Sample: Importance of Neurodevelopmental and Neurotransmitter Genes. Biological Psychiatry, Vol. 63, Issue. 9, p. 864.

Zhu, Gu Hewitt, Alex W. Ruddle, Jonathan B. Kearns, Lisa S. Brown, Shayne A. MacKinnon, Jane R. Chen, Christine Y. Hammond, Christopher J. Craig, Jamie E. Montgomery, Grant W. Martin, Nicholas G. and Mackey, David A. 2008. Genetic Dissection of Myopia. Ophthalmology, Vol. 115, Issue. 6, p. 1053.

Erickson, Stephen 2008. A Likelihood-Ratio Test of Twin Zygosity Using Molecular Genetic Markers. Twin Research and Human Genetics, Vol. 11, Issue. 1, p. 41.

Distel, M. A. Trull, T. J. Derom, C. A. Thiery, E. W. Grimmer, M. A. Martin, N. G. Willemsen, G. and Boomsma, D. I. 2008. Heritability of borderline personality disorder features is similar across three countries. Psychological Medicine, Vol. 38, Issue. 9, p. 1219.

Hansell, Narelle K. Agrawal, Arpana Whitfield, John B. Morley, Katherine I. Zhu, Gu Lind, Penelope A. Pergadia, Michele L. Madden, Pamela A. F. Todd, Richard D. Heath, Andrew C. and Martin, Nicholas G. 2008. Long-Term Stability and Heritability of Telephone Interview Measures of Alcohol Consumption and Dependence. Twin Research and Human Genetics, Vol. 11, Issue. 3, p. 287.

Middelberg, Rita P. Gordon, Scott D. Zhu, Gu McRae, Allan Montgomery, Grant W. Martin, Nicholas G. and Whitfield, John B. 2008. Linkage and Association Analyses of Longitudinally Measured Lipid Phenotypes in Adolescence. Twin Research and Human Genetics, Vol. 11, Issue. 6, p. 603.

Lind, Penelope A. Macgregor, Stuart Agrawal, Arpana Montgomery, Grant W. Heath, Andrew C. Martin, Nicholas G. and Whitfield, John B. 2008. The Role of GABRA2 in Alcohol Dependence, Smoking, and Illicit Drug Use in an Australian Population Sample. Alcoholism: Clinical and Experimental Research, Vol. 32, Issue. 10, p. 1721.

Macgregor, Stuart Lind, Penelope A. Bucholz, Kathleen K. Hansell, Narelle K. Madden, Pamela A.F. Richter, Melinda M. Montgomery, Grant W. Martin, Nicholas G. Heath, Andrew C. and Whitfield, John B. 2009. Associations of ADH and ALDH2 gene variation with self report alcohol reactions, consumption and dependence: an integrated analysis. Human Molecular Genetics, Vol. 18, Issue. 3, p. 580.

Haworth, Claire M. A. Wright, Margaret J. Martin, Nicolas W. Martin, Nicholas G. Boomsma, Dorret I. Bartels, Meike Posthuma, Danielle Davis, Oliver S. P. Brant, Angela M. Corley, Robin P. Hewitt, John K. Iacono, William G. McGue, Matthew Thompson, Lee A. Hart, Sara A. Petrill, Stephen A. Lubinski, David and Plomin, Robert 2009. A Twin Study of the Genetics of High Cognitive Ability Selected from 11,000 Twin Pairs in Six Studies from Four Countries. Behavior Genetics, Vol. 39, Issue. 4, p. 359.

Hansell, Narelle K. Agrawal, Arpana Whitfield, John B. Morley, Katherine I. Gordon, Scott D. Lind, Penelope A. Pergadia, Michele L. Montgomery, Grant W. Madden, Pamela A. F. Todd, Richard D. Heath, Andrew C. and Martin, Nicholas G. 2009. Can We Identify Genes For Alcohol Consumption In Samples Ascertained For Heterogeneous Purposes?. Alcoholism: Clinical and Experimental Research, Vol. 33, Issue. 4, p. 729.

Lind, Penelope A. Luciano, Michelle Horan, Michael A. Marioni, Riccardo E. Wright, Margaret J. Bates, Timothy C. Rabbitt, Patrick Harris, Sarah E. Davidson, Yvonne Deary, Ian J. Gibbons, Linda Pickles, Andrew Ollier, William Pendleton, Neil Price, Jackie F. Payton, Antony and Martin, Nicholas G. 2009. No Association Between Cholinergic Muscarinic Receptor 2 (CHRM2) Genetic Variation and Cognitive Abilities in Three Independent Samples. Behavior Genetics, Vol. 39, Issue. 5, p. 513.

Townsend, Grant Hughes, Toby Luciano, Michelle Bockmann, Michelle and Brook, Alan 2009. Genetic and environmental influences on human dental variation: A critical evaluation of studies involving twins. Archives of Oral Biology, Vol. 54, Issue. , p. S45.

Distel, Marijn A. Trull, Timothy J. Willemsen, Gonneke Vink, Jacqueline M. Derom, Catherine A. Lynskey, Michael Martin, Nicholas G. and Boomsma, Dorret I. 2009. The Five-Factor Model of Personality and Borderline Personality Disorder: A Genetic Analysis of Comorbidity. Biological Psychiatry, Vol. 66, Issue. 12, p. 1131.

Lind, Penelope A Luciano, Michelle Wright, Margaret J Montgomery, Grant W Martin, Nicholas G and Bates, Timothy C 2010. Dyslexia and DCDC2: normal variation in reading and spelling is associated with DCDC2 polymorphisms in an Australian population sample. European Journal of Human Genetics, Vol. 18, Issue. 6, p. 668.

Haworth, C M A Wright, M J Luciano, M Martin, N G de Geus, E J C van Beijsterveldt, C E M Bartels, M Posthuma, D Boomsma, D I Davis, O S P Kovas, Y Corley, R P DeFries, J C Hewitt, J K Olson, R K Rhea, S-A Wadsworth, S J Iacono, W G McGue, M Thompson, L A Hart, S A Petrill, S A Lubinski, D and Plomin, R 2010. The heritability of general cognitive ability increases linearly from childhood to young adulthood. Molecular Psychiatry, Vol. 15, Issue. 11, p. 1112.

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On the Probability of Dizygotic Twins Being Concordant for Two Alleles at Multiple Polymorphic Loci

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