SARS-CoV-2-specific T cells associate with inflammation and reduced lung function in pulmonary post-acute sequalae of SARS-CoV-2
Fig 2
Cytokine co-expression of SARS-CoV-2 specific T cells differs between PASC and RC.
Cytokine co-expression on SARS-CoV-2 specific T cells visualized using simplified presentation of incredibly complex evaluations (SPICE) analysis. Each pie chart represents the proportions of combinations of IFN-γ, TNF-α and IL-2 producing T cells in response to one SARS-CoV-2 protein. Arcs surrounding each pie chart depict the proportion of cells secreting each individual cytokine. Colors of pie charts and arcs represent different cytokines or combinations of cytokines and are listed in the corresponding legend. Stars denote significant differences determined by student t test corrected for multiple comparsons between PASC and RC cohorts for a particular combination of co-expressed cytokines matching as indicated by the color corresponding to the pie legend. Stars are positioned next to the cohort with the higher proportion. P values positioned between PASC and RC pie charts denote statistical significance of overall composition by permutation test with 10,000 iterations corrected for multiple comparsons.