Transient viral replication during analytical treatment interruptions in SIV infected macaques can alter the rebound-competent viral reservoir
Fig 1
Viral replication dynamics in plasma and PBMC CA-DNA.
Four Indian-origin Rhesus macaques were infected with SIVmac239M on day 0 and treated with ART on day 10. Viral RNA (copies per mL) were measured in plasma over 843 days with values below 15 copies/mL shown in grey. The animals underwent three treatment interruptions, between 313 to 336 dpi, 444 to 462 dpi, and 682 to 699 dpi. CD8 depletion with anti-CD8α mAb was performed 3 days prior to the last two ATIs. CA-vDNA (per 106 PBMC) was also quantified via qPCR at various times post infection.