PD-1 is imprinted on cytomegalovirus-specific CD4+ T cells and attenuates Th1 cytokine production whilst maintaining cytotoxicity
Fig 7
Model of the association of viral load with the PD-1+ population, and functional relevance.
(a) Viral load during primary infection defines the PD-1+ ‘set point’ of the subsequent CMV-specific CD4+ T cell response, high viral load results in higher PD-1+ CD4+ T cell populations. (b) CMV specific cells encountering target cells. PD-1+ T cells possess equal cytotoxic, but display lower release of cytokine to the microenvironment following interaction with PD-1 ligand expressing target cells.