Subclinical in utero Zika virus infection is associated with interferon alpha sequelae and sex-specific molecular brain pathology in asymptomatic porcine offspring
Fig 8
Sex-specific molecular pathology in the prefrontal cortex of offspring affected with subclinical in utero ZIKV infection.
(A) Venn diagram of individual and shared GO processes in the female and male subgroups. FDR adjusted P < 0.1. See raw data in S2K–S2M Tables for individual process values. Enrichment map of significantly altered GO biological processes in the prefrontal cortex of female (B) and male (D) offspring affected with subclinical in utero ZIKV infection. Pathways with positive (red) and negative (blue) enrichment are shown. All subnetworks with FDR-adjusted P < 0.1 and at least three connected nodes are shown. (C) Positive (red) and negative (blue) enrichment of neuronal and behavioral GO processes in female and male subgroups. FDR adjusted P < 0.05.