Asymmetric antiviral effects of ebolavirus antibodies targeting glycoprotein stem and glycan cap
Fig 1
Panel of mAbs from human survivors of natural ebolavirus infections selected for the study.
Schematic representation of EBOV GP domain structure: RBD, receptor-binding domain; GC, glycan cap; MLD, mucin-like domain; IFL, internal fusion loop; MPER, membrane proximal external region. Positions of the first amino acid of each domain are indicated. The black asterisk indicates the C-mannosylation site. For each antibody, positions of escape mutations [26] are indicated. EC50 and IC50 values greater than 10,000 ng/ml are indicated “>”.