Phenotypic deficits in the HIV-1 envelope are associated with the maturation of a V2-directed broadly neutralizing antibody lineage
Fig 8
SU-like sensitive and SU-like VRC26 early escape viruses are differently neutralized post CD4 attachment.
A: Interdependencies of pre- or post-attachment activity and IC50 for free virus (left) or cell-cell neutralization (right). Spearman correlations on untransformed data sets with R and p values are shown. Neutralization data are derived from data sets depicted in Fig 2, pre- and post- attachment data are derived from data sets depicted in Fig 7. PI-like, SU-like VRC26 sensitive and SU-like VRC26 early escape viruses are marked in red, light blue and dark blue respectively. B: Pre- and post-attachment inhibition and loss in activity after CD4 attachment based on data depicted in Fig 7 were compared for SU-like VRC26 sensitive and SU-like early escape viruses using the Mann-Whitney test. P values are indicated.