The Kaposi's sarcoma-associated herpesvirus (KSHV) non-structural membrane protein K15 is required for viral lytic replication and may represent a therapeutic target
Fig 10
K15 is abundantly expressed in KS tissue biopsies.
(A) IF staining, using antibody clone number 18E5, of K15 (red) in sections prepared from paraffin embedded blocks of HuARLT2 or HuARLT2-rKSHV cells. (B) KS tissue biopsies obtained from HIV positive individuals were stained for K15/DAPI by IF (first column), LANA (dark brown nuclei), CD34 (red) and Hematoxylin and Eosin (last column); the respective KSHV genotype (K15P or M) was determined by PCR and is shown on the right. NA—staining not available because of insufficient biopsy material.