Malaria-induced interferon-γ drives the expansion of Tbethi atypical memory B cells
Fig 9
The frequency of febrile malaria episodes associates with increased T-bethi B cells.
Percent of CD19+ B cells that were (A) T-betint or (B) T-bethi before and after a two-year period of intensive clinical surveillance in age-matched children who had either ≤1 (n = 15) or ≥5 (n = 5) febrile malaria episodes during the same period. (C) Fold change of T-betint and T-bethi CD19+ B cells from before to after the two-year surveillance period in children who had either ≤1 or ≥5 febrile malaria episodes. p values were determined by paired Student’s t test with Bonferroni adjustments where appropriate. ****P<0.0001, ***P<0.001, **P<0.01, *P<0.05, ns = not significant.