Platelet proteome reveals novel pathways of platelet activation and platelet-mediated immunoregulation in dengue
Fig 1
Distribution of mapped proteins in platelets from dengue patients and healthy volunteers.
(A) Venn diagram of mapped protein entries present in platelets from healthy volunteers (Control) and patients with dengue. Both conditions shared 2,557 proteins; 339 and 440 proteins were identified only in control or dengue platelet samples, respectively. (B) Volcano plot of all shared protein entries and their abundance in dengue and control conditions. The graph represents TFold pairwise analysis of the two biological conditions. Each dot represents a protein mapped according to its log2 (fold change) on the ordinate axis and its -log2 (t-test p-value) on the abscissa axis. Red dots indicate proteins that satisfy neither the fold-change cutoff nor the FDR cutoff α (0.05). Green dots depict protein entries that satisfy the fold-change cutoff but not FDR α. Orange dots indicate proteins that satisfy both fold-change and FDR α, but present low fold changes. Blue dots represent protein entries that satisfy all statistical filters. The result shows 86 proteins significantly up-regulated (blue dots above the dotted line on Volcano plot) and 81 proteins down-regulated (blue dots below the dotted line on the graph) in platelets from patients with dengue.