Zika Virus infection of rhesus macaques leads to viral persistence in multiple tissues
Fig 1
Cohort design and timeline used for ZIKV infection of rhesus macaques.
Graphical depiction of the cohorts and timeline used for the infection of Rhesus monkeys with ZIKV. Blood and urine were collected daily for the first 10 days post infection and then at 14, 21, 28, and 35 dpi. Cohorts 1 and 2 and 3 were taken to necropsy at 28, 7, and 35 dpi, respectively. Cohort 1 was used to examine ZIKV dose effect and viral persistence. Cohorts 2 and 3 was used to determine viral tissue tropism during acute infection as well as at later times after resolution of serum viremia. Monkey identification number, age and sex as well as the infectious dose of ZIKV used to infect the animals are listed for each cohort.