Sterol Biosynthesis and Azole Tolerance Is Governed by the Opposing Actions of SrbA and the CCAAT Binding Complex
Table 2
CBC mutants show increased production of sterols.
Sterol levels of transcription factor mutants incubated in AMM for 24 h at 37 C, 200 rpm have been determined by GC-MS. Δcyp51A served as control for the double deletion mutant ΔhapCΔcyp51A. Sterol content has been normalised to that of wt. Samples were assessed in biological triplicates. p-values were calculated by Student’s T-test (reference: wt): *, <0.05; ** <0.01. TS, total sterols; bold, >1.5 fold increase.