Staphylococcal Bap Proteins Build Amyloid Scaffold Biofilm Matrices in Response to Environmental Signals
Fig 7
Biological relevance of Bap amyloids.
A) Effect of Bap fibers in S. aureus adhesion to epithelial cells. Adhesion of S. aureus V329 wild type and Δbap mutant to the mammary gland epithelial cells MAC-T. Bacterial adhesion was determined after 1 hour of infection. Data represent the means from three independent experiments (**, P<0.01). B) In vivo biofilm formation of S. aureus V329 wild type and Δbap mutant using a catheter infection model. Catheters were infected with equal numbers of the strains, and bacteria were recovered from implanted catheters and counted after 4 or 10 days post-infection. Asterisks indicate significant differences P<0.05. ns, no significant differences. Statistical analysis was performed using the Mann–Whitney test.