Defensins Potentiate a Neutralizing Antibody Response to Enteric Viral Infection
Fig 4
MAdV-1 loads are higher in Mmp7-/- mice than wild type only late in infection.
Weight change from measure to measure for each (A) wild type or (B) Mmp7-/- mouse is shown after infection with 1x105 i.u. of MAdV-1 by oral gavage. Open gray symbols containing an “x” denote the two mice that were humanely euthanized due to illness. MAdV-1 genomes in (C) fecal pellets or the ratio of MAdV-1 genomes to cellular genomes in (D) brain, (E) spleen, and (F) distal ileum were quantified by qPCR. Data are the individual values for each wild type (closed symbols) or Mmp7-/- (open symbols) mouse overlaid with the group mean ± SD (n = 6 except for fecal samples on days 0–9, where n = 12). For all graphs, **P = 0.001–0.01 and ***P<0.001 comparing wild type and Mmp7-/- mice on the same day. Unmarked days were not significant (P>0.05). Dashed lines in (C-F) indicate the limits of detection.