Polyfunctional HIV-Specific Antibody Responses Are Associated with Spontaneous HIV Control
Fig 4
Antibody functionality can be predicted by subclass composition.
A. Correlative relationships between levels of total gp120-specific IgG or gp120-specific antibodies of each subclass to antibody function were assessed by determination of Spearman’s rank correlation coefficients between activity and antibody MFI within each subject group. B. Correlative relationships between relative levels of gp120-specific antibodies of each subclass (i.e., MFI of subclass/MFI of total IgG) were assessed for each functional activity, over all subjects. Positive associations are noted in blue and inverse associations in red, with the magnitude of correlation depicted by intensity. Correlative relationships and significance were calculated and visualized using R, with unadjusted p values indicated to facilitate relative comparisons. C. The magnitude and direction of the contribution of SF162-specific antibody subclass assessments to cross-validated predictive models of polyfunctional activity.