An Evolution-Based Screen for Genetic Differentiation between Anopheles Sister Taxa Enriches for Detection of Functional Immune Factors
Fig 3
Leucine-rich repeat (LRR) proteins play contrasting roles in the choice between normal and melanized parasite fates.
A. The activity of APL1C but not LRR7037 restricts permissiveness of mosquitoes to P. yoelii infection, measured as oocyst infection prevalence. B. APL1C function also limits the efficiency of parasite development within infected mosquitoes, measured as infection intensity. LRR7059 and LRR7037 have no effect (S2 Table). C. Loss of function of either APL1C or LRR7037 is accompanied by reduced levels of parasite melanization. In the absence of APL1C activity, the non-melanized parasites appear to develop normally (compare C with A), while in the absence of LRR7037 activity, the non-melanized parasites nevertheless are apparently still killed. Graph labels and statistical tests as in Fig 2 legend.