Evolutionary and Functional Analysis of Old World Primate TRIM5 Reveals the Ancient Emergence of Primate Lentiviruses and Convergent Evolution Targeting a Conserved Capsid Interface
Fig 4
An evolutionarily-guided model for TRIM5α binding to capsid hexamers.
A. A capsid hexamer colored according to the key to highlight the sites identified in this study that modulate sensitivity to both Papionini and Cercopithecini TRIM5αs and their relation to sites that mediate contacts with cellular cofactors. A dashed circle shows the position of the β-hairpins. Black arrows point to a cluster of sensitizing mutations that sit between sites that mediate contacts with cyclophilin A/Nup-358-cypA-like domain, and those that mediate contacts with CPSF6/Nup-153. B. A model of TRIM5α (shades of orange) placed on the capsid hexamer. The V1 loops are colored yellow and indicated by yellow arrows. C and D are side views of A and B respectively. This model is based on a TRIM5 model published in Goldstone et al., 2014 [92] and provided by Ian Taylor.