IFNγ and IL-12 Restrict Th2 Responses during Helminth/Plasmodium Co-Infection and Promote IFNγ from Th2 Cells
Fig 6
IFNγ production by Th2 cells does not depend of type I IFN.
A). CD4+TCRβ+Il4gfp+Ifnar+/+ or Ifnar–/–Th2 cells were transferred to Rag1–/–mice. Recipient mice were infected with 105 P. chabaudi 14 days later and mice were harvested at day 8 post-infection. B and C). Cytokine expression in transferred cells in the spleen (ICS). D). IFNγ protein in serum, measured by ELISA. E). Percent parasitemia, determined by blinded counting of Giemsa-stained blood smears. F). Hemoglobin and red blood cell counts determined by Vetscan. Data are representative of 2 independent experiments with 5–6 mice per group. * denotes P<0.05.