Identification of Anti-virulence Compounds That Disrupt Quorum-Sensing Regulated Acute and Persistent Pathogenicity
Figure 4
M64 reduces pyocyanin production in P. aeruginosa clinical multi-drug resistant strains.
a. Quantitative pyocyanin production in multi-drug resistant clinical P. aeruginosa isolates plus (red) and minus (black) 5 µM M64. A representative image of qualitative pyocyanin production, visible as green media, in PA14 culture +/− M64, is shown above the histogram. b. Antibiotic resistance profile of P. aeruginosa clinical strains and their respective isolation sites from infected patients. Amik. = amikacin, Gent. = gentamycin, Mero. = meropenem, Pip. = piperacin, Tobra. = tobramycin, Cefe. = cefepime, Aze. = azetromycin, Cip. = ciprofloxacin. R = resistant; I = intermediate; S = sensitive.