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Identification of Anti-virulence Compounds That Disrupt Quorum-Sensing Regulated Acute and Persistent Pathogenicity

Figure 4

M64 reduces pyocyanin production in P. aeruginosa clinical multi-drug resistant strains.

a. Quantitative pyocyanin production in multi-drug resistant clinical P. aeruginosa isolates plus (red) and minus (black) 5 µM M64. A representative image of qualitative pyocyanin production, visible as green media, in PA14 culture +/− M64, is shown above the histogram. b. Antibiotic resistance profile of P. aeruginosa clinical strains and their respective isolation sites from infected patients. Amik. = amikacin, Gent. = gentamycin, Mero. = meropenem, Pip. = piperacin, Tobra. = tobramycin, Cefe. = cefepime, Aze. = azetromycin, Cip. = ciprofloxacin. R = resistant; I = intermediate; S = sensitive.

Figure 4

doi: https://doi.org/10.1371/journal.ppat.1004321.g004