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Host-Specific Enzyme-Substrate Interactions in SPM-1 Metallo-β-Lactamase Are Modulated by Second Sphere Residues

Figure 3

Residues present at positions 84 and 121 in selected mutants for each antibiotic selection and library in P. aeruginosa PAO.

IMI = imipenem, PCL = piperacillin, CAZ = ceftazidime, CXT = cefoxitin.

doi: https://doi.org/10.1371/journal.ppat.1003817.g003