Viral Escape from HIV-1 Neutralizing Antibodies Drives Increased Plasma Neutralization Breadth through Sequential Recognition of Multiple Epitopes and Immunotypes
Figure 7
Maturation of the wave 2 CD4bs response results in the increased neutralization breadth of CAP257 plasma.
A) Summary of early (green) and late (blue) heterologous neutralization by wave 2 antibodies superimposed over the individual virus neutralization kinetics (grey). Viruses neutralized by V2 antibodies in wave 1 have been excluded. ID50 titers (y-axis) are shown versus weeks p.i. (x-axis). B) Amino acid sequence alignment of heterologous viruses depicted in (A). The timing of early or late heterologous neutralization is shown on the left with horizontal lines. The N276 glycan is shaded grey, and position 279 is boxed in orange. The frequency of the N279D mutation or disrupted N276 glycosylation within the two groups is shown with orange or purple pie slices respectively. The N-terminal region of the D-loop is boxed in blue.