Maintenance of Intestinal Th17 Cells and Reduced Microbial Translocation in SIV-infected Rhesus Macaques Treated with Interleukin (IL)-21
Figure 3
Effects of IL-21 on blood and intestinal T cell levels in SIV-infected RMs.
Longitudinal assessment of the percentages (A, C) and absolute numbers expressed as cells per µl (B, D) of circulating CD4+ (A, B) and CD8+ (B, D) T cells in IL-21-treated and controls RMs. (E–F) Longitudinal assessment of intestinal CD4+ T cells expressed both as fraction of total CD3+ T cells (E) and as fold change relative to the percentages of CD4+ T cells at wk2 (F). IL-21-treated animals are depicted in orange, controls in black. Shaded area represents time of IL-21 treatment. Averaged data are presented as mean ± SEM.