Structure of Human Cytomegalovirus UL141 Binding to TRAIL-R2 Reveals Novel, Non-canonical Death Receptor Interactions
Figure 2
Comparison of the UL141 and TRAIL binding footprints on TRAIL-R2.
TRAIL-R2 is shown as a grey molecular surface in three different orientations: left (a), front (b), and right (c). The binding interface between the UL141 and TRAIL-R2 (c) is divided into six binding patches, with patches 3 and 5 being similar to that of the TRAIL–TRAIL-R2 complex (a). TRAIL contact residues on TRAIL-R2 in cyan (a–b), UL141 contact residues on TRAIL-R2 in yellow (b–c), while the overlapping residues are green (b).