Linking the Transcriptional Profiles and the Physiological States of Mycobacterium tuberculosis during an Extended Intracellular Infection
Figure 2
Electron microscopy analysis of long-term Mtb-macrophage interactions.
(A–B) Intracellular Mtb (indicated by “M”) 2 hr p.i., with individual bacilli occupying typical tight phagosomes (A) and clusters contained in loosely apposed spacious vacuoles (B). (C–D) Damaged and degraded Mtb (asterisk) associated with phagolysosomes (P-L) at 2 days p.i. (E–F) Macrophages with heavy bacterial burden at day 6 (E) and day 8 (F) p.i.