Nonequivalence of Classical MHC Class I Loci in Ability to Direct Effective Antiviral Immunity
Figure 2
Spinal cord demyelination and persistent virus infection in FVB Kbα1α2Db transgenic mice.
(A) Transgenic expression of H-2Kb fails to protect from TMEV induced demyelination, similar to non-transgenic control (B). (C) Expression of H-2Db transgene protects FVB mice from TMEV induced demyelination present in littermate controls (D). (E) Expression of a chimeric Kbα1α2Db molecule fails to protect from demyelination, similar to non-transgenic (F). (G) Relative TMEV RNA levels in spinal cords from transgenic mice infected for 21 days (* p<0.05 by ANOVA). (H) Relative TMEV RNA levels in the brains of transgenic mice after 24 days of infection.