Robust Antigen Specific Th17 T Cell Response to Group A Streptococcus Is Dependent on IL-6 and Intranasal Route of Infection
Figure 3
Primary intranasal GAS infection induces a Th17 response.
Mice were inoculated once intranasally with 2×108 CFU or equivalent numbers of heat-killed streptococci HK-GAS. (A) CD4+CD44Hi2W:I-Ab+ cells enriched from spleens of mice that were inoculated with live GAS-2W and restimulated after a week in vivo by IV injection of heat killed GAS-2W (HK-GAS-2W). (B) CD4+CD44Hi2W:I-Ab+ cells from mice that were inoculated intranasally with heat-killed GAS-2W and restimulated in vivo with HK-GAS-2W. One representative of three independent experiments is shown.