A Helminth Immunomodulator Exploits Host Signaling Events to Regulate Cytokine Production in Macrophages
Figure 7
Perturbation of ERK and p38 in the mathematical model.
Mathematical models can be used to make in silico predictions when a single parameter of a system is changed. Model 15 was used to analyze the effect of ERK and p38 perturbation on ERK, on p38, on DUSP and on IL-10 mRNA. We used the perturbation factors 10 and 0,1 to mimic a parameter increase and decrease of the indicated component, respectively.