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Protective Efficacy of Cross-Reactive CD8+ T Cells Recognising Mutant Viral Epitopes Depends on Peptide-MHC-I Structural Interactions and T Cell Activation Threshold

Figure 3

Structure of the DbNP366–374 and DbNPN3A complexes.

The H2Db molecule is in a cartoon representation with the α1-helix on the back and the α2-helix removed for better clarity. The peptide is represented in stick conformation with the C terminus on the right. (A) The NPN3A is in purple and (B) the NP366 in blue, with the p3 mutation in yellow. (B) Overlay of the peptide-binding cleft for H2DbNP366 and H2DbNPN3A with the α1-helix on top and the α2-helix on the bottom. (C) Contacts with the H-2Db molecule by (C) P3N in NP366 and (D) P3A in NPN3A. The Asn3 mutation to alanine abolishes contacts between the P3 residue of the peptide with His155 and the Tyr156 of the H-2Db.

Figure 3

doi: https://doi.org/10.1371/journal.ppat.1001039.g003