Entry and Fusion of Emerging Paramyxoviruses
Figure 2
Proteolytic processing of the henipavirus fusion proteins.
(A) Schematic of F protein cleavage/activation. FP, fusion peptide; HR1 and HR2, heptad repeat; S-S, disulfide bond; TM, transmembrane domain. (B) Model for proteolytic processing of the henipavirus F proteins. The Hendra or Nipah F proteins are synthesized in the endoplasmic reticulum (ER), transit through the secretory pathway to the plasma membrane (PM), and are subsequently endocytosed. Following interaction with cathepsin L at an undetermined point in the endocytic pathway, the cleaved protein is recycled to the plasma membrane.