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Increased Monocyte Turnover from Bone Marrow Correlates with Severity of SIV Encephalitis and CD163 Levels in Plasma

Figure 3

Percentage of BrdU+ monocytes does not correlate with plasma virus or CD4+ T lymphocyte turnover or numbers.

A. Paired XY values for percentage of BrdU incorporation in CD4+ T lymphocytes and monocytes in all infected animals are plotted. No correlation is found between the percentage of BrdU+ monocytes and the percentage of BrdU+ CD4+ T lymphocytes (P = 0.2379). B. Paired XY values for percentage of BrdU incorporation monocytes and CD4+ T lymphocyte counts in all seven infected animals are plotted. No correlation is found between the percentage of BrdU+ monocytes and CD4+ T cell counts (P = 6641). C. Paired XY values for percentage of monocyte BrdU incorporation and plasma viral load in all infected animals are plotted. No correlation is found between the percentage of BrdU+ monocytes and plasma viral loads P = 7880. D. Paired XY values for percentage of BrdU+ CD4+ T cells and plasma virus in all infected animals are plotted. No correlation is found between the percentage of BrdU+ CD4+ T cells and plasma viral loads P = 0.3701. A Spearman rank test is used for statistics.

Figure 3

doi: https://doi.org/10.1371/journal.ppat.1000842.g003