P58IPK: A Novel “CIHD” Member of the Host Innate Defense Response against Pathogenic Virus Infection
Figure 8
P58IPK functions as an inhibitor of the apoptotic and inflammatory responses during influenza virus infections.
During influenza virus infection, P58IPK and PKR are activated. While P58IPK-mediated inhibition of PKR results in decreased apoptotic and inflammatory responses, the absence of P58IPK results in the amplification of these responses via increased Caspase, eIF2α, and NF-κB activation. Molecules shaded light grey were up-regulated in infected P58IPK−/− mice at the transcript level while those shaded dark grey were up-regulated at the protein level. In tandem, the enhancement of these responses results in increased mortality in P58IPK−/− mice.