Development and application of a next-generation sequencing protocol and bioinformatics pipeline for the comprehensive analysis of the canine immunoglobulin repertoire
Fig 14
IGH clonality by clinical outcome.
Circle size scaled to clonotype frequency (left) and VJ junction circos plots (right) at T1 and T2 for individual cases with complete remission (D02219), partial remission (D02154), and stable disease treated only with prednisone (D02741). Clonotype with highest frequency at T1 is labeled with CDR3 amino acid sequence and V and J genes. The same clonotype is labeled at T2 if identified within the repertoire.