Circulating extracellular vesicles exhibit a differential miRNA profile in gestational diabetes mellitus pregnancies
Fig 5
Differential abundance of EV-derived miRNAs in gestational diabetes mellitus (GDM) pregnancies.
Heatmap showing expression of placenta-specific C19MC and C14MC in EVs isolated from non-pregnant women (NP), and during 1st, 2nd, 3rd trimesters and at delivery (del) in normal pregnancy (NORM) and gestational diabetes (GDM) (A). Volcano plots display miRNAs from EVs isolated from gestational diabetes mellitus (GDM) (B) compared to normal pregnancies, during the first trimester of pregnancy. Red dots represent downregulated miRNAs, white dots represent miRNAs that are not significant for differential expression, blue dots represent upregulated miRNAs, green dots represent miRNAs from the C14MC and orange dots represent miRNAs from the C19MC.