Disruptions in hepatic glucose metabolism are involved in the diminished efficacy after chronic treatment with glucokinase activator
Fig 2
HbA1c, plasma glucose and plasma insulin levels in the chronic treatment study.
Time course of (a) HbA1c level, (b) plasma glucose level, and (c) plasma insulin level during the chronic treatment study. Normal; Wistar rats, Control; Goto-Kakizaki rats fed normal diet, n = 7–8. *p < 0.05, NS = not significant.