Therapeutic doses of acetaminophen with co-administration of cysteine and mannitol during early development result in long term behavioral changes in laboratory rats
Fig 3
Weight of pups during the course of the experiment.
In Panel A, the average weight of pups per litter on Day P3, prior to administration of acetaminophen or saline, is shown. The average weights of pups in litters born to mothers with a Western diet and experimentally induced psychological stress were much more widely distributed (21.1% coefficient of variation) than were average weights of pups in litters born to animals without a Western diet and psychological stress (“Normal”; 1.5% coefficient of variation; F test: p = 0.0002). In Panel B, changes over time in the average pup weight per litter in animals without a Western diet and experimentally induced psychological stress are shown. Panel C shows the weights of individual pups born to animals without a Western diet or experimentally induced psychological stress as a function of acetaminophen exposure versus saline as a control. Pups exposed to acetaminophen weighed on average 13.2% less than pups receiving saline (t test: p < 0.0001), despite having essentially the same average weights on day 3 prior to initiation of drug exposure (Panel B).