Identification of immunodominant linear epitopes from SARS-CoV-2 patient plasma
Fig 4
Selected epitopes localization in relation to the protease cleavage site of the spike protein.
A-B) The 655–672 epitope (red) and the two reported protease cleavage sites S1/S2: site 1 (685–686: blue) and site 2 (695–696: cyano). C) Sequence alignment of the S1/S2 cleavage sites for five different coronaviruses SARSCov2(2019), SARSCov (2003), HCovHKU1, HCovNL63, HCOVOC43 and HCov229E. D-E) The 787–822 epitope (green) and the S2’ cleavage site (815–816: magenta). F) Sequence alignment of the S2’ cleavage site. Figure generated from pdb ID: 6ZGE.