Induced pluripotent stem cell-derived monocytic cell lines from a NOMID patient serve as a screening platform for modulating NLRP3 inflammasome activity
Fig 4
Dose-dependent inhibition of IL-1β (closed circles) and IL-6 (open circles) secretion from PBMCs of a healthy donor. Cells were stimulated with LPS (20 ng/ml) for 4 hours and ATP (2 mM) for an additional hour. Bars show the mean ± SD of four wells.