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Hypusinated eIF5A is expressed in the pancreas and spleen of individuals with type 1 and type 2 diabetes

Fig 3

eIF5AHyp is robustly expressed in the pancreatic polypeptide-expressing PP cells in the islet.

(A-D) In both controls and T2D pancreas, co-expression of eIF5AHyp with pancreatic polypeptide (PP) and chromograninA (ChgA) was observed. (E) An expression pattern of eIF5AHyp in the PP cells suggestive of localization to the ER was observed in cells in both controls and T2D pancreas.

Fig 3

doi: https://doi.org/10.1371/journal.pone.0230627.g003