Combination treatment of berberine and solid lipid curcumin particles increased cell death and inhibited PI3K/Akt/mTOR pathway of human cultured glioblastoma cells more effectively than did individual treatments
Fig 9
Combination treatments increased p53 and decreased c-Myc levels in U-87MG and U-251MG cells more than did single treatments.
A-C: Western blot data showed that SLCP+BBR increased p53 and decreased c-Myc levels significantly more in U-87MG and U-251MG cells, in comparison to single treatments. Similarly, immunofluorescence signals of c-Myc was decreased (D-E) and p53 was increased (F-G) more in SLCP+BBR-treated U-87MG cells than in SLCP- or BBR-treated cells. Scale bar indicates 100 μm and is applicable to other images. *p<0.05, **p<0.01 and ***p<0.001.