Metabolic requirements of human pro-inflammatory B cells in aging and obesity
Fig 1
DN B cells do not proliferate.
Naïve and DN B cells were sorted from the peripheral blood of 4 young (white symbols) and 8 elderly (black symbols) individuals. Sorted cells were stimulated with CpG and anti-Ig antibodies, together with IL-4. Proliferation of sorted B cell subsets was measured after 2 day stimulation by 3H-Thymidine incorporation. Mean comparisons between groups were performed by one-way ANOVA. ****p<0.0001, ns: not significant.