Elk1 affects katanin and spastin proteins via differential transcriptional and post-transcriptional regulations
Fig 4
(A) Transfection of SH-SY5Y cells with either Elk1 or Elk1-3R constructs was controlled for similar expression levels of both. (B) Both Elk1 and Elk1-3R promote the transcription of KATNA1, significantly. SEM values for control, Elk1, and Elk1-3R experiments are 0, 0.07, 0.04, respectively. Each experiment was performed as triplicates on the same day and the experiments were repeated three times on separate days, independently (n = 3). (C) mRNA level of SPG4 is increased due to Elk1 and Elk1-3R. SEM values for control, Elk1, and Elk1-3R experiments are 0, 0.12, 0.06, respectively. Each experiment was performed as triplicates on the same day and the experiments were repeated three times on separate days, independently (n = 3).