Pharmacological AMPK activation induces transcriptional responses congruent to exercise in skeletal and cardiac muscle, adipose tissues and liver
Fig 2
Effects of AMPK activators on glucose clearance and glycogen mobilization in lean C57BL/6 mice.
Effects of LA1 (30 mg/kg, PO) and SA1 (30 mg/kg, PO) on glucose tolerance, target engagement and glycogen at 1h and 24h post-dose (n = 8). (A) Blood glucose/time curve in an ipGTT. (B) AUC of the blood glucose/time curve. (C) pACC/ACC ratio in skeletal muscle. (D–E) Glycogen contents of skeletal muscle and heart. Data are represented as mean ± SEM. *p < 0.05, **p < 0. 01, *** p < 0.001 relative to vehicle.